Part A: The Molecular Basis of Cell and Tissue Organisation Cell and Tissue Organisation Regulation of the Cell Cycle Overview of Oncogenesis Inherited Predispositions to Cancer Human DNA Tumour Viruses RNA Viruses Genomic Instability and DNA Repair Telomerase Signalling by Steroid Receptors Signalling by Cytokines Signalling by Tyrosine Kinases Signalling by TGF- /chb/articles/chap13/frame.html Wnt Signal Transduction Extracellular Matrix: The Networking Solution Invasion and Metastasis Angiogenesis Cell Proliferation in Carcinogenesis Part B: The Causation and Prevention of Cancer Identifying Cancer Causes Through Epidemiology Mechanisms of Chemical Carcinogenesis The Formation of DNA Adducts Physical Causes of Cancer Non-Genotoxic Causes of Cancer Infectious Agents and Cancer Short-Term Testing for Genotoxicity Cancer Bioassays for Pharmaceuticals: A Regulatory Perspective Molecular Epidemiology of Cancer Dietary Genotoxins and Cancer Tobacco Use and Cancer Occupational Causes of Cancer Antigenotoxins and Cancer Intervention and Chemoprevention of Cancer Part C: Systemic Oncology Introduction to the Diagnosis of Cancer Skin Oral Cavity and Major and Minor Salivary Glands Respiratory System Upper Gastrointestinal Tract Lower Gastrointestinal Tract Liver, Gall Bladder and Extrahepatic Bile Ducts Pancreas Endocrine Organs Breast Female Reproductive System Urinary Tract Male Genital Tract Lymph Nodes Bones Soft Tissues Pleura and Peritoneum Heart Neuromuscular System Eye and Ocular Adnexa Ear Blood and Bone Marrow: Myeloid Leukaemias and Related Neoplasms Part D: Pre-clinical Models for Human Cancer Advantages and Limitations of Models for Cancer and Malignant Cell Progression Basic Tissue Culture in Cancer Research Transgenic Technology in the Study of Oncogenes and Tumour-Suppressor Genes Gene Knockouts in Cancer Research Human Tumours in Animal Hosts Mammary Tumour Induction in Animals as a Model for Human Breast Cancer Mathematical Models in Cancer Research Models for Tumour Growth and Differentiation Angiogenesis Models Models for Tumour Cell Adhesion and Invasion Tumour Metastasis Models Models for Tumour Cell—Endothelial Cell Interactions Modelling Tumour Tissue Interactions Models for Drug Development and Drug Resistance Models for Immunotherapy and Cancer Vaccines Gene Therapy Models Models for Epithelial Carcinomas Haematological Malignancies in Cancer Research Models for Melanomas and Sarcomas Models for CNS Malignancies Models for Endocrine Cancer: Uterine Carcinoma as an Example Part E: Diagnostic Imaging and Image-guided Intervention Plain Film Radiography Computed Tomography Ultrasound Magnetic Resonance Imaging Nuclear Medicine Breast Imaging and Diagnosis Percutaneous Biopsy Transcatheter Therapy Direct Percutaneous Tumour Therapy Part F: The Treatment of Human Cancer (and Issues Related to Treatment) Mechanisms of Action of Cancer Chemotherapeutic Agents: Antimetabolites Mechanisms of Action of Cancer Chemotherapeutic Agents: DNA-Interactive Alkylating Agents and Antitumour Platinum-Based Drugs Mechanisms of Action of Cancer Chemotherapeutic Agents: Topoisomerase Inhibitors Mechanisms of Action of Cancer Chemotherapeutic Agents: Antimicrotubule Agents Mechanisms of Action of Cancer Chemotherapeutic Agents: Antitumour Antibiotics Drug Resistance and Reversal Molecular Mechanisms of Radiotherapy Antibodies and Recombinant Cytokines Genetic and Cellular Vaccines Differentiation Therapy Chemoprevention Antisense and Ribozyme Therapy Hormonal Therapy for Breast Cancer Antiangiogenic Therapy Targeting the Extracellular Matrix Growth Factor Receptor Blockade Signal Transduction Pathway Targeting DNA Repair and the Cell Cycle as Targets in Cancer Therapy Gene Therapy — Tumour-suppressor Gene Replacement/Oncogene Suppression Genetic Prodrug Activation Therapy (GPAT) Stem Cell Transplantation Novel Surgical Strategies in the Management of Cancer Translational Research (Overview of Phase I, II and III Clinical Trials)